
One of the more common complaints about Android is its lack of aesthetic appeal or polish, especially compared to that of iOS and even Windows Phone 7. While Android is not by any means ugly, it almost certainly seems to lack that special something its competitors have. In all likeliness, a quick glance at your phone will reveal a random array of icons, widgets, and folders scattered among your home screens in no particular order.
A typical Android homescreen.

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Preparation
The first of those apps that you need is a custom launcher like ADW.Launcher, Go Launcher EX, Zeam Launcher, or my personal preference, LauncherPro, all of which you’ll find have free versions in the Market. Using any of these launchers will allow you to choose everything from the number of home screens you have, to which apps you will have set for quick access on your dock. A launcher goes a long way in keeping your home screen looking clean, as they will allow you to keep a lot of the clutter that your icons create confined to the dock area. And, importantly, they don’t restrict you to the 4×4 grid of default launchers.
SiMi Folder offers an attractive folder layout.

The second app you will want is SiMi Folder Widget, also available for free in the Market. Unlike Android built-in folder functionality, SiMi Folder Widget gives you the ability to choose a custom icon, hide the name of the folder which usually appears under the default icon, and set how you want the actual folder popup menu to appear. Its a hugely versatile app that does wonders for reducing the amount of clutter on your screen.
Now, if you are anything like I was, chances are your home screen looks pretty similar to the image above. You will have your core apps that you access frequently like Gmail, Maps, and the camera, a few games like Angry Birds that you like to have easy access to when you need to kill some time, and a few widgets lying around just to make things a little more convenient. Its all functional, yes, but its cluttered.
Full tutorial over here.
http://www.youmobile.org/blogs/entry/How-to-Clean-Up-Your-Android-Phone-Home-Screen